Scientists at Colossal have successfully edited seven genes in mice embryos to create mice with long, thick, woolly hair. The extra-furry rodents were nicknamed the “Colossal woolly mouse,” and the results were posted online but have not yet been published in a journal or reviewed by independent scientists. This achievement is considered technologically impressive and more efficient thanks to new technologies like CRISPR.
The scientists at Colossal identified genes related to hair texture and fat metabolism by reviewing DNA databases of mouse genes. These genetic variations are already present in some living mice, but Colossal combined them all in a single mouse. The traits chosen are likely related to cold tolerance, a quality necessary for woolly mammoths to survive on the prehistoric Arctic steppe.
Initially focusing on mice to confirm the process works, Colossal hopes to eventually edit the embryos of Asian elephants, the closest living relatives to woolly mammoths. However, due to the endangered status of Asian elephants, there will be significant challenges and regulations to navigate before any plans can move forward. Colossal has raised over $400 million in funding for this research.
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